Lineage Factor

The Lineage Factor is the blueprint of life itself, present in all living organisms. It was discovered by a research team led by Dr. Vegapunk and Vinsmoke Judge.

Overview
All lifeforms have the Lineage Factor, and by manipulating it from a young age, the growth of a lifeform can be changed. Eating a Devil Fruit affects one's Lineage Factor, which allows them to gain a supernatural power. Conversely, the Lineage Factor of one who bears a Devil Fruit power can be studied and duplicated, making it possible to recreate the consumed fruit itself to be eaten by someone else, or to alternatively fashion a blood substitute bearing the unnatural traits of the fruit-user in question, and potentially making it so that more than one individual could have the same ability granted by a single Devil Fruit, which would otherwise be impossible since each and every Devil Fruit in existence is individually unique as are the individuals who are empowered by them.

Artificial Devil Fruits
By extracting Kaidou's Lineage Factor, Dr. Vegapunk was able to replicate the Emperor's Uo Uo no Mi, Model: Seiryu at some point in the past. Despite interest from the World Government in the replica, however, Vegapunk deemed the experiment a "failure" due to its color, leaving it behind in the Third Research Institute after Caesar Clown caused an island-wide explosion on Punk Hazard. Because of this, the World Government believed the replica was lost among the destruction.

The replicated fruit, however, was left intact, being eventually found and eaten by a starving Momonosuke. In spite of having little control over its effects, Momonosuke is still able to transform into a full dragon and summon flame clouds for flight, meaning that despite being a "failed" experiment, the fruit works very closely to the way an actual Zoan Devil Fruit functions.

Green Blood
Green Blood is another application of Lineage Factor discovered by Vegapunk, which consists of a synthetic liquid akin to blood that can somehow manifest the effects of Paramecia Devil Fruits when infused in a Pacifista's body. In this case, it was developed as a workaround to allow his Seraphim project to be equipped with Paramecia abilities, which are otherwise unable to be replicated in fruit form.

SAD
By applying Lineage Factor, Caesar Clown was able to create SAD, a key ingredient used in the development of Artificial Devil Fruits known as SMILES, as explained by Trafalgar Law. However, they are restricted to the Zoan-class.

Modified Humans
While his wife was pregnant, Judge forced her to undergo the surgery which manipulated the Lineage Factor of the four fetuses she was carrying. However, due to Sora's interference, only three of their four sons were born as modified humans. After their birth, they were further experimented on, including being administered drugs, in order to increase their development. These experiments were also performed on their elder sister.

The successfully modified sons (Ichiji, Niji and Yonji) developed an Exoskeleton (外骨格), gained an increased healing ability, and, with training, rapidly increased in strength and resilience; soon, these qualities developed to a point equaling those of adult soldiers, while the children were in their early childhood. Supposedly, the modifications also took away their ability to feel emotions. However, Ichiji, Niji, and Yonji are able to be attracted to pretty women, laugh at jokes, and ridicule Sanji.

While Reiju received the same physical enhancements, she retained her emotions, but lost the ability to refuse Judge's orders. Sanji, after wearing the Raid Suit several times, seemingly begins to develop genetic enhancements as well.

Cloning
Vinsmoke Judge conducted several researches and experiments with the Lineage Factor, becoming able to artificially manufacture human beings to fill the soldier ranks of Germa 66. Those soldiers are known as Clone Soldiers (兵) and they are made without the knowledge of their origin.

Trivia

 * The Lineage Factor is a reference to DNA, the molecule that contains all the genetic information of the host organism.

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