Isshi-100

The Isshi-20 (イッシー20（トゥエンティ）) were the twenty most skilled doctors on Drum Island, whom Wapol took for himself in order to make his subjects grovel at his feet for their services around the start of the series.

The Isshi-100 (イッシー100（ワンハンドレッド）) are the Isshi-20 renamed two years after their introduction, as they have found eighty additional doctors, becoming a group of one hundred doctors.

Appearance
They are one hundred different doctors who dress in scrubs with sunglasses. They constantly have surgery mask and gloves on them. They are all of varying height with similar builds and most of the time stand as if prepping for surgery. The Isshi-20 from two years ago are wearing pink scrubs, but the color for the scrubs the Isshi-100 are currently wearing remains unconfirmed.

Abilities and Powers
The Isshi-20 were skilled enough to save Wapol's life even after he has been decapitated. As the Isshi-100, their individual capabilities as doctors has not yet been delved into.

Service Under Wapol
While they were under Wapol's control, they secretly despised and hated him as the rest of the people did. However, they gave in to the king in order to continue their research and refine their techniques. Upon seeing the quack, Dr. Hiluluk's, noble sacrifice, the Isshi-20 became determined to never lose to the quack. To this end, they hoped to use their research and techniques to help their compatriots. When Wapol fled the kingdom, he took the Isshi-20 with him.

After Wapol was defeated, they were forgiven by the people of the island and rejoined them as citizens of the new Sakura Kingdom.

Service to the Sakura Kingdom
Two years later, we see the Isshi-20 has grown to become the Isshi-100, working for Kureha at Sakura Kingdom's medical center.

Translation and Dub Issues
"Isshi" is derived from "Ishi" (医師), which means "doctor". In the English version, the Isshi-20 are accurately translated as "doctors" or "MDs", meaning medical doctor.