Modified Humans

Modified humans are humans who have been scientifically modified to have enhanced traits.

Appearance
Modified humans are basically normal humans with artificial enhancements made at a genetic level. So far, the only known modified humans are four of the five children of the Vinsmoke Family. Their external appearances are identical to that of normal humans.

Modified Humans

 * Vinsmoke Reiju
 * Vinsmoke Ichiji
 * Vinsmoke Niji
 * Vinsmoke Yonji

Biology
Modified humans are humans whose Lineage Factor has been manipulated, usually at the embryonic stage. By manipulating this "blueprint of life", the growth of the life form in question can be changed accordingly.

Vinsmoke Judge engineered his four sons to possess superhuman traits, by applying the procedure onto them during their fetus stage, against the wishes of his wife, Sora. By doing so, he ensured they would develop a secondary, hardened skeleton known as an Exoskeleton (外骨格), lose their capacity for empathy or compassion, have an increased healing ability, and (with training) rapidly increase in strength and resilience to the point equalling an adult man while in their early childhood.

Vinsmoke Sanji is the only one of the four Vinsmoke quadruplets to not gain any of the genetic enhancements his father attempted to imprint onto him, due to his mother taking in a powerful drug in an attempt to negate the surgery's effects. Although Ichiji, Niji and Yonji all adapted to their father's engineering, the drug rendered Sanji alone in remaining a "normal human".

Vinsmoke Reiju, although not born alongside her four brothers, was also modified by her father to possess such enhancements, but with some alterations: she cannot disobey direct orders, but retains her emotions and can circumvent his orders with loopholes.

Cultural Relationships
Modified humans bring up the issue of benefits versus ethical considerations: while Judge was adamant of turning his four sons into superhuman commanders for his Germa 66, Sora was against the idea of negating their ability to feel compassion. Sora fiercely believed that such modifications would render their children to be inhuman, and she went as far as to intake a powerful drug in an attempt to negate these modifications, which only worked on Sanji or some part of Reiju since she can retain some of her emotion and being the only sibling that cares for Sanji; in exchange, the drug caused Sora to weaken until a premature death.

Due to their lack of compassion and upbringing, the three male modified humans of the Vinsmoke Family look down on others with a royal haughtiness, and are willing to kill and injure in cold blood, and even in a sadistic sense, such as ordering soldiers to sacrifice their own lives or brutally attacking a devoted chef to vent out frustrations. Their cruelty extends even to their brother, Sanji, whom they see as a failure due to his failure to adapt to the genetic modifications and retaining his humanity. However, they remain loyal to their father and kingdom.

Overall Strength
The modified humans engineered by Judge possess an exoskeleton, which grants them enhanced durability, leading them to be renowned for their "iron bodies". They also possess an increased healing rate, as Reiju managed to heal within hours of Charlotte Pudding shooting her left leg with special Candy Jacket bullets. With training, their strength and resilience would rapidly increase to the point equalling an adult man's, while in their early childhood. Further administration of drugs can also further the augmentations.

Judge also modified his sons to lose their emotions of empathy and compassion, in order to increase their combat efficiency. Because of this, the three sons who adapted to the modifications are utterly incapable of sympathy for people outside of their family, instead believing themselves above all others; Reiju considers them to lack humanity as a result.

Reiju and Niji have both demonstrated special abilities, from which they derived their epithets: Reiju's ability ("Poison Pink") allows her to suck out poison out of an afflicted individual via kissing, with no ill effects (in fact, she enjoys their taste); Niji's ability ("Electric Blue") allows him to generate electricity from his body.

Limits
The Exoskeleton, while powerful, is not invincible. A powerful enough force can cause it to dent, although it can be repaired with a counter blunt-force, such as a hammer or a "Press Machine". Should something like the jaw be dislocated, the modified human in question can rearrange it by hand. The special "Candy Jacket" bullets utilized by Pudding managed to pierce through Reiju's exoskeleton, causing her left leg to bleed profusely.

Modified humans are as vulnerable to Devil Fruit powers to any normal human, as Reiju's memories were successfully modified by Pudding without difficulty.

It is also shown that all three Vinsmoke members: Ichiji, Niji, and Yonji are not only lack of emotion but also their fear of death as the result they don't try to figure out how to get out of dangerous situation when they are being pointed a gun in their head by Charlotte family members. As the result, this traits backs fire Judge horribly. Even Reiju states that these three Vinsmoke boys are barely human since they are nothing more than killing machine.