User blog comment:Fliu/Chapter 942: Another Tragedy for Wano/@comment-4401815-20190510145810/@comment-2600:6C5D:5D00:1C9:9D81:E1A:3B12:32AD-20190516173454

The SAD chemical used to make SMILE was made by Caesar Clown then transfers it to Doflamingo's factory in Dressrosa made by the dwarves to sell them to Kaido and other consumers. The factories in Wano are simply quaries and weapon factories. How the SMILEs affect the area is still unknown.