SAD

SAD is a substance produced in a lab within Punk Hazard, D Block. It was first alluded to in a conversation by Vergo, before being revealed to be Trafalgar Law's true goal on Punk Hazard.

Properties
SAD is a particularly rare substance able to create Smiles, artificial Zoan Devil Fruits. It has the potential to cause chaos within the New World, depending on the one who wields it. It also might have some radioactive properties, as the symbol for radioactive substances appeared on the tank Law was looking at. Caesar Clown is the only person in the world who knows how to manufacture this substance. As such, SAD is very valuable, as Donquixote Doflamingo suggested destroying the production room and killing Caesar to prevent it from being stolen and the scientist from being kidnapped, only to retract the suggestion as it would be troublesome for him to lose his supply of the substance as well as any chance of procuring more.

Punk Hazard Arc
Vergo arrived on Punk Hazard shortly after catching a ride on an SAD tanker ship that was leaving from Dressrosa. Trafalgar Law apparently went through great lengths to gain access to the SAD production room on Punk Hazard, joining the Shichibukai and then forming an alliance with the Straw Hat Pirates. He eventually succeeded amidst the chaos in the research facility, but Vergo contacted Doflamingo and reported it. Vergo was ordered to stop Law from taking the SAD and execute him for his betrayal, which leads to the two of them battling in the production room. After Law and Smoker fought and defeated Vergo, Law broke the gears in the production machine, halting the production of SAD forever.