User blog:Awareness Bringer/Free Modification Human vs. Modified Humans

This has been on my mind lately, even before User:Norman Fong Ochoa asked on Kaido's recent blog. Both he and I have been wondering if those who have consumed the Ope Ope no Mi have the power to work their way around the Modified Humans, regarding those who appear to lack the superpowers (Vinsmoke Sanji), those who are conditioned to obey orders (Vinsmoke Reiju), and those who are dead in the empathy portion of the Human psyche (Vinsmoke Ichiji, Vinsmoke Niji, and Vinsmoke Yonji). I like thinking and writing about what ifs, so I'm sure you can understand my curiosity. What do you all think?