User blog comment:Uknownada/Brook the only eater?/@comment-4493594-20111022082754

Nope. He is probably not the first one to eat it. He knew what kind of Devil Fruit he had even before he ate it, right? Which means there must be a record on what it does somewhere and that means someone ate it before.

I thought about this before myself and I would say the term "darn hard to kill" is more accurate than "immortal". For one thing he said that as long as his bones are intact, no damage is done. I suppose if the damage exceeds a certain point he can't pull himself together again (literally). So If you grind his bones to flour he definitely won't be able to revive. Further we don't know how long his second life lasts. It's probably the lifespan of another human life, so about 80-90 years. That means he might have another 30-40 years to live and then he dies a natural death.