Poison

Poison is a general term that refers to natural substances and chemical weapons that are toxic to organic lifeforms. Poison can come in different forms and phases, and it can have various effects on the victims, depending on its composition. This can range from illness, paralysis to death. Poison can be derived from a wide range of sources, including being created by chemical engineering, or secreted naturally from animals or plants as a defense mechanism.

Antidotes
Although poison can be harmful to the body, some of them have a counteracting agent, known as an antidote (解毒剤). They can defuse the poison within the body, saving the victims from death or other harmful effects. However, some poisons do not have an antidote, or some antidotes may be difficult and time-consuming to create.

Other Treatments
Outside of antidotes, there are other forms of treatment which can allow a person who has been poisoned to survive. However, these treatments are often rare, being tied to unique abilities. They include Ivankov's Devil Fruit-based hormone treatments, and Vinsmoke Reiju's ability to absorb and suck out poisons. Through the use of her Shibo Shibo no Mi, Charlotte Smoothie can also wring liquids, including poisons, out of human bodies.

Poison in One Piece
In the series, there are several characters who use poison to fight. This grants a huge advantage in battle, as their opponents do not typically develop immunity to such toxins (as opposed to a swordsman who can block sword slashes, or someone like Monkey D. Luffy who takes little damage from blunt attacks like punches). This weakens the opponent, giving the poison user a greater opportunity to strike.

Monkey D. Luffy has developed an extremely high resistance (if not quasi-immunity) to most poison. Primarily due to his near-death experience against Magellan's poisonous Devil Fruit, his body started producing antitoxins (antibodies) to neutralize future poisons and foreign toxins without issue. However, he remains susceptible to poisons known to be extremely lethal such as the toxic skin of an Armored Stonefish. On the other hand,Vinsmoke Reiju, whose epithet is "Poison Pink" (ポイズンピンク), is completely immune to poison and can even consume it as a form of nourishment. She described the Armored Stonefish's toxin as a delicacy after absorbing the whole quantity of it in Luffy's body, enough supposedly able to kill a giant.

Certain Devil Fruit users gain immunities from poisons due their respective powers being affiliated with poison, such as Magellan and Caesar Clown (poisonous gases only). In Magellan's case, however, he is still affected by diarrhea as he enjoys consuming the poison.

Poison-Weapon Users

 * Don Krieg has among his personal arsenal the Deadly Poison Gas Bomb: MH5, which is a grenade launcher whose grenades release poisonous gas, usually lethal to those who breathe it. Krieg claimed that the MH5 is strong enough to annihilate an entire village. He and his men are given gas masks to protect themselves from it. The only known antidote is contained within the gas masks as stated by Zeff. He also makes use of poisonous spears, though these have been replaced by suction cups in the 4Kids Entertainment dub.
 * Nami, during her eight years of servitude under the Arlong Pirates, tried many times to kill Arlong, among them attempting to poison him.
 * Crocodile's left hand is replaced by a golden hook. When the golden cover is removed, it reveals a hidden hook inside coated with scorpion venom. The poison appears to be acidic in large quantities and is concentrated enough to dissolve rocks. The poison causes paralysis and eventual death from cardiac arrest. Nico Robin was carrying a bottle of antidote for this poison.
 * Wanze uses a giant knife covered in a one-hit sure kill deadly poison in his Ramen Kenpo's final technique: Noodle-Cutting Poisonous Kitchen-Knife.
 * The unnamed pirate crew that massacred the Rumbar Pirates coated their weapons with poison to give themselves an edge in battle. As the Rumbars' doctor was killed in battle, the crew had no means of saving themselves from death.
 * Duval uses a harpoon gun with the ammunition being coated with scorpion poison. The poison will kill the victim within three minutes.
 * The New Fish-Man Pirates' Hyper Toxic Squadron used poison-based weapons. The poison contained in their weapons is very strong, as just one prick is enough to kill a person instantly.
 * Hyouzou, a blue-ringed octopus merman and officer of the New Fish-Man Pirates, can inject deadly venom into opponents directly and coat his swords with it.
 * The Yeti Cool Brothers use bullets containing the sleeping gas KYP and other types of poison.
 * Caesar Clown developed various poison gas-based weapons, including Shinokuni, Smiley, and Koro. His Devil Fruit in turn renders him immune to gaseous poisons like those he creates.
 * Gladius uses poison on the tip of his hair, turning them into poisonous needles which he can eject using the Pamu Pamu no Mi.
 * Vinsmoke Reiju uses poison in combat, usually by secreting it and injecting it into opponents as she makes physical contact.

Devil Fruit Based Poisons
There are certain Devil Fruit powers that can grant its eaters the ability to create poison.
 * Boa Marigold ate the Hebi Hebi no Mi, Model: King Cobra, allowing her to transform into a King Cobra and spit highly toxic venom at her opponents.
 * Magellan ate the Doku Doku no Mi, granting him the ability to create various types of poison, as well as makes him immune to all forms of poison. Each type has various effects. Alone, these poisons seem to have an antidote all their own, but if accumulated, curing them could prove difficult, if not impossible.
 * Hydra: a semi-corrosive liquid poison that causes lethal nerve paralysis until the victim dies after 24-hours of pain. The liquid can also be launched in bubbles known as "Poison Blowfish". Fire seems to somewhat neutralize it, while wax and stone are resistant to it.
 * Chloro Ball: a bubble that releases a tear gas poison and immobilizes the victims through severe sneezing. Guards of Impel Down wear gas masks to protect themselves from this.
 * Poison Cloud: a widespread poisonous cloud that slowly robs the victims of their vision, hearing, and strength. Guards of Impel Down wear gas masks to protect themselves from this.
 * Kinjite: Magellan's ultimate poison, it spreads like a disease upon contact with anything, even inorganic materials like wax and rocks. It causes the victims to die instantly once the poison spreads completely through the infected body. It is capable of destroying all of Impel Down.


 * Caesar Clown ate the Gasu Gasu no Mi, allowing him to create, control, and transform into gas at will. His gas is shown to exhibit poisonous qualities.

Anime Only

 * Wapol, in the ninth movie, ate his brother Musshuru with his own Baku Baku no Mi, allowing him to create poisonous spores like his brother.
 * Musshuru, a movie-exclusive character from the ninth movie, ate the Noko Noko no Mi, which allows him to control and generate poisonous mushroom spores. These spores can be lethal enough to destroy the entire Drum Island, but they are instantly destroyed when they come into contact with fire. An antidote was used by Nico Robin on Monkey D. Luffy.

Natural Poison Sources

 * Amber Lead: a white-colored ore, native to Flevance, which has no symptoms at first, but over time it gives the victims white hair and skin. All infected person's descendants will have their lifespans shortened and die at an earlier age. Trafalgar Law prevented his death this way by curing himself via the abilities of the Ope Ope no Mi.
 * Amiudake: a very poisonous mushroom that will kill anyone who eats it in one hour. Tony Tony Chopper unknowingly fed one to his mentor Hiriluk, but the doctor took his own life via an explosive concoction before the poison could kill him.
 * Desert Strawberry: a poisonous spider that strongly resembles a strawberry, killing anyone who eats it after a few hours, and spreads its toxin after, poisoning anyone in the vicinity.
 * Giant Snake: a gigantic snake that releases a very corrosive venom.
 * Yuda: ferocious and poisonous sea serpents domesticated by the Kuja Pirates of Amazon Lily that even Sea Kings do not dare attack.
 * Puzzle Scorpions: very poisonous scorpions that can combine into gigantic centipedes.
 * A giant jellyfish in the underworld of the sea, which killed a giant fish that ate it.
 * Armored Stonefish: a giant fish whose skin is extremely poisonous, enough to instantly kill those who consume them in normal circumstances, even a giant. Even Luffy's acquired resistance could not neutralize the venom, only preventing him from dying immediately. His condition worsened in a short time span as none of the antidote aboard of his ship worked. He was only saved by the intervention of Reiju, who considered this toxin as a delicacy and ate it without an issue using her own ability.

Anime-Only

 * Agehaguera: a giant butterfly that releases toxic pollen when it flaps its wings.
 * Daft Green: a species of tree that releases deadly spores.

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