Ice Oni

Ice Oni is an artificial virus created by Queen, which he has weaponized with Excite Bullets. According to him, it is his best creation, referred to as his "masterpiece".

Description
Once a person is struck by an Excite Bullet with this virus, their skin will become covered in ice, causing them to feel extremely cold. The ice will take on a demonic shape, causing the victim to grow a pair of horns from their head and their teeth will turn into sharp fangs, giving them the appearance of oni.

Once their body is covered in ice, a victim appears to lose their sense of reasoning, entering a berserk state and targeting anyone around them, regardless of whether they are an ally or enemy. Moreover, they receive a boost in physical strength and durability due to an increase in muscle mass, making them nearly impossible to defeat through regular means since they will just get up once more after being knocked down (with Roronoa Zoro comparing their endurance to that of Zombies). According to Tony Tony Chopper, the virus' symptoms cause too much strain on the victim's body, leading to their eventual death in around a hour, as confirmed by Queen.

This virus can quickly spread from person to person through physical contact, with one victim being shown biting an uninfected person with his sharp teeth to transmit it. Because of this, fighting back a victim requires one to use a weapon or another object to avoid physical exposure to the virus. The only way to cure Ice Oni is through an antibody created by the virus' developer himself, Queen, who happens to have the only known existing sample somewhere in his person.

Wano Country Arc
When war broke out at the Live Floor in Onigashima between the Ninja-Pirate-Mink-Samurai Alliance and the Beasts Pirates, Queen fired Excite Bullets from a gatling gun at the enemy samurai, intending on closing off the room and spreading the virus to everyone in it.

Trivia

 * This virus is named after the children's game "freeze tag", which is known in Japan as "Ice Oni" (こおり鬼).
 * It somewhat resembles the rabies virus, as rabies also alters the victim's behaviour and cause them to attack bystanders
 * It might also be based on the popular "zombie virus" that appears in many forms of media, where infected people turn into mindless zombies that attack and spread the virus further.

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