User blog comment:Fliu/The Reasons Big Mom Has To Go Down/@comment-24850639-20170313193655/@comment-1784001-20170315034957

The only ways for Big Mom not being a threat if she's still alive are either she's locked up/sealed away or she suffer a severe injury that would take away the use of her limbs. So far in the series, the Straw Hats never gave their opponents extremely gruesome injuries like with what Jack did to Inuarashi and Nekomamushi. Bege might be the one to severely cripple Big Mom.

Even if Crocodile and Buggy are not major antagonists anymore, they may still have a role in the future.