User blog comment:AYET/Shanks missing arm/@comment-3119203-20120222021707

No, he couldn't. He would not have anything to regenerate. Think of it like this: while the fruit is not active, anything done to the user is as if it was done to a regular person. When the fruit is reactivated, it is as if it is from a whole new person: all the damage that was done before is still there. Like Akainu could not heal the wounds Whitebeard did to him and neither could Ace in his BB fight.