Modified Humans

Modified humans are humans who have been biologically modified through genetic enhancements to have enhanced physical traits. So far, the only known modified humans are the five children of the Vinsmoke Family.

Appearance
Modified humans are normal humans with artificial enhancements made at a genetic level. Their external appearances remain identical to that of normal humans. However, genetic enhancements can cause changes to appearance not inherited from one's parents, as none of the Vinsmoke children (except Sanji) inherited their parents' hair colors, and all share the feature of both of their eyebrows curling into a spiral on one side.

Sanji, who's genetic modifications were initially negated by his mother taking a drug while he was in the womb, is unique among his siblings, both because his hair color is the same as his parents', and because the spirals on his eyebrows are on their left, rather than their right. However, after wearing his associated Raid Suit multiple times, causing his dormant enhancements to awaken, his eyebrows briefly became the same as his siblings'.

Biology
Modified humans are humans whose Lineage Factor has been manipulated, usually at the embryonic stage. By manipulating this "blueprint of life", the growth of the life form in question can be changed accordingly.

Vinsmoke Judge engineered his four sons to possess superhuman traits, by applying the procedure to them during their fetus stage, against the wishes of his wife, Vinsmoke Sora. By doing so, he ensured they would develop a secondary, hardened skeleton known as an Exoskeleton (外骨格), as well as other physical enhancements. However, while Ichiji, Niji, and Yonji all adapted to their father's engineering, Sanji did not gain any of the genetic enhancements due to their mother taking a powerful drug intended to negate the surgery's effects. The drug rendered Sanji alone a "normal human" at birth, but only until recently when he would later awaken his genetic enhancements during the raid on Onigashima. Sanji realizes that his augmented body was the result of wearing his raid suit. Sanji's genetic modifications compared to his brothers, affected only his body due to having a fully developed set of emotions before it awakened. His new augmented body grants him far more power than he had before.

Reiju, although not born alongside her four brothers, was also modified by her father to possess such enhancements, but rather than being born without emotions, she was modified to prevent her from directly disobeying Judge.

Cultural Relationships
Modified humans broach a controversial topic about the morality of genetic engineering, its benefits and drawbacks. Judge, a warrior king, was adamant about turning his four sons into superhuman commanders for the family's army, Germa 66, while his wife Sora was against the negation of their ability to feel compassion. Sora fiercely believed that such modifications would render their sons inhuman, to the point that she consumed a powerful drug in an attempt to negate their effects; this drug only worked on Sanji, and conversely caused permanent damage to Sora's health that lead to her premature death eight years later. Reiju, three years older than her brothers, was also subjected to a different variant enhancement which similarly give her superhuman physical potential and an exoskeleton. However, the procedure interfered with her emotional capacity in a different manner; she cannot disobey direct orders, but retains her natural compassion and can resist or circumvent her father's commands with loopholes.

Due to their lack of inherent compassion in conjunction with their royal and militant upbringing, the three modified brothers of the Vinsmoke Family look down on others with utter haughtiness, and are willing to kill and injure in cold blood. This includes wanton acts of cruelty, such as ordering soldiers to sacrifice their own lives for them, or brutally attacking a devoted chef to vent out dinner frustrations. Their cruelty extends to their mutual quadruplet brother, Sanji, whom they see as a failure due to his lack of genetic enhancements and his capacity to empathize. Beyond this cruel and self-superior nature, the three brothers are generally less emotional than a normal human being; in particular they have no personal fear of injury or death, traits intended to make them effective warriors. Judge's goal was for this trait, in tandem with a calculating efficiency to avoid injury purely out of pragmatism only, to render them master combatants and killing machines, but to his horror it proves to be a great flaw. When the Vinsmoke family were surrounded by the Big Mom Pirates and restrained at gunpoint without arms or effective armor, the modified brothers quickly assessed that, having no means to retaliate, defend, or escape their predicament, there was nothing for them to do; the family had simply lost, and so they sat there unconcerned, accepting defeat and death nonchalantly. The trio joked about how badly they had been deceived; and when their father, who was more naturally upset over the impending death of himself and his children, began to plead and cry, they coldly deemed him a failure in contrast with their usual respect. Not even their own beloved father's sentiment mattered to them in that dire situation. Judge, witnessing this flawed design in their genetic engineering, desperately thought at last that something was wrong with them. Despite these flaws, Judge was correct that the modifications would make the brothers more effective warriors. Even after being mowed down in a hail of gunfire, the Vinsmokes barely reacted to their injuries and continued to fight against Big Mom's soldiers, only beginning to retreat after they had completed their mission.

Because of the horrible treatment he was given as a child, Sanji resented his brothers as well as his father. After escaping from the Germa Kingdom in the East Blue, Sanji made a new life for himself as a cook while not ever mentioning his true relations to anyone. When he was forced to reunite with his blood family, he was reminded constantly of how cruel they all were to him in the past, but was unable to disobey them due to Judge's threat against his adoptive father. However, his sister, Reiju was the only one to show him any compassion to him, even replacing the wristbands that were rigged to explode if Sanji tried to escape with normal ones. Also, after learning of the Big Mom Pirates' plot to kill his family, Sanji desired to save them despite the abuse they put him through, and later claimed that it was only because his "real" father would disagree with Sanji's decision to leave them for dead. In return for his deed, his father and siblings fought hard against the Emperor's crew to allow Sanji and his own crew to escape from Totto Land, though they stated that they simply did not wish to be indebted to a "failure", showing that their opinion of him did not change in the slightest.

When Sanji noticed the raid suit that was secretly granted by his siblings, Sanji initially refused to use it due to his hatred for his family, but kept it despite wanting to throw it away. Later on in Wano, Sanji ultimately decided to use it in order to conceal his identity while fighting with Page One, granting him great power and the ability to turn invisible (which he used to peep on women in the bathhouse like he always dreamed of doing). He then used it again during the raid on Onigashima to save Momonosuke from being executed, but then began to feel unusual afterwards. During his fight with Queen, he realized that by wearing the suit, it began to awaken the dormant modifications that his mother gave her life to prevent him from getting, granting him greater strength and resistance from injury. Upon seeing this, Queen became ecstatic of fighting one of his former colleague's inventions to prove his superiority, but Sanji became fearful of becoming a heartless killing machine like his brothers and ran off. After an encounter with a woman he supposedly attacked, Sanji decided to destroy the raid suit in order to prevent himself from losing his human emotions as well as cut off all ties with his family; he even requested for Zoro to kill him should he end up a different person after the battle. His new modifications did prove useful, allowing his body to withstand greater heat than before, thus allowing him to develop his new Ifrit Jambe technique to finally defeat Queen.

Overall Strength


The modified humans engineered by Judge all possess superhuman physical strength. During their childhood, with training, the four Vinsmoke siblings' strength and resilience rapidly increased to the point of equaling an adult man's. Further administration of drugs can also further the augmentations. In Sanji's case, due to having developed an extremely powerful body from years of training, his latent enhancements when fully awakened proved more formidable than his siblings as he could knock down Queen, a cybernetically enhanced Ancient Zoan Devil Fruit user and one of the Beast Pirates' All-Stars.

The Vinsmoke siblings also possess an exoskeleton which grants them enhanced durability, leading them to be renowned for their "iron bodies". They also possess an increased healing rate, as Reiju managed to rapidly heal after her leg was shot, and was even able to engage in combat a few hours later. A more extreme case was shown where Sanji survived being crushed to death, with all his broken bones heal and reformed in a matter of seconds.

Special Abilities
Reiju, Ichiji, Niji, Sanji and Yonji have demonstrated special abilities which resemble the use of Devil Fruits or other abilities. The abilities which have been demonstrated are tied to the user's epithet:


 * Reiju's ability is "Poison Pink" (ポイズンピンク), which allows her to suck out powerful poisons out of an afflicted individuals and neutralize them within her body, demonstrating complete immunity to the deadliest poisons. She is also able to secrete poison to attack enemies, an ability similar to the Doku Doku no Mi and Gasu Gasu no Mi.
 * Ichiji's ability is "Sparking Red" (スパーキングレッド), which allows him to generate energy beams and explosions from his body, similar to the Pika Pika no Mi and Bomu Bomu no Mi.
 * Niji's ability is "Dengeki Blue" (デンゲキブルー), which allows him to generate electricity from his body, similar to the Goro Goro no Mi and Electro.
 * Sanji's ability is "Stealth Black" (ステルス・ブラック), which allows him to become invisible from his body, similar to the Suke Suke no Mi.
 * Yonji's ability is "Winch Green" (ウインチグリーン), which allows him to possess tremendous grappling power. His gauntlets can extend outward, gripping and punching with incredible force.

Limits


The Exoskeleton, while powerful, is not invincible. A powerful enough force can cause it to dent, although it can be repaired with a counter blunt-force, such as a hammer or a "Press Machine". Should something like the jaw be dislocated, the modified human in question can rearrange it by hand. The Charlotte Family also developed special "Candy Jacket" bullets capable of piercing through Reiju's exoskeleton, causing her left leg to bleed profusely.

Modified humans are as vulnerable to Devil Fruit powers as any other normal human, as Reiju's memories were successfully modified by Pudding without any difficulty.

Additionally, there are notable limitations to the modifications' accompanying impact on emotional capacity. While Judge originally perceived Ichiji's, Niji's, and Yonji's lack of emotions as a strength in combat, it proved a limitation when they responded indifferently to the prospect of imminent death. As Reiju retained her emotions and humanity, she grew to despise her father and brothers (except Sanji), and was forced to carry out her father's orders in a way which conflicted with her innate moral nature. However, while Judge's modifications on Reiju prevent her from directly opposing him, they do not appear to prevent Reiju from undermining his orders indirectly, as she replaced Sanji's exploding wrist bracelets with fakes. Reiju was also able to choose not to warn her family about Big Mom's imminent plan to betray and kill them, showing that she retains a large degree of autonomy. Ironically, while Judge had always viewed Sanji as a failure due to his compassion and humanity, it was this very compassion that led Sanji to rescue his family despite the years of mistreatment he received at their hands, an act that shocked Judge and moved Reiju.

It appears that genetic modifications can only remove a limited range of natural human emotions and cannot alter the subject's natural personality. Despite their loss of "soft" emotions such as empathy and compassion, Ichiji, Niji, and Yonji are still capable of feeling such emotions as anger and cruel delight, and they all exhibited a lecherous streak at the sight of Nami. They also rescued Nami, Chopper, and Carrot from the clutches of the Big Mom Pirates at Sanji's behest, implying that the brothers are still capable of showing gratitude in limited ways, even towards people they detest.

Trivia

 * Their name mostly takes inspiration from the alias of the Kamen Riders, from the franchise of the same name.
 * Queen has referred to the Vinsmoke siblings as "cyborgs", although still using the kanji for "modified human".

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