Ice Oni

Ice Oni is an artificial virus created by Queen, which he has weaponized with Excite Bullets. According to him, it is his best creation, referred to as his "masterpiece".

Description
Once a person is struck by an Excite Bullet infused with this virus, their skin will become covered in ice, making them feel extremely cold. The ice will take on a demonic shape, causing a pair of horns and sharp fangs to manifest on the victim's head and mouth, giving them the appearance of oni.

Once their body is covered in ice, the victim appears to lose their sense of reasoning and enters a berserk state, targeting anyone around them, ally or not. Moreover, they receive a boost in physical strength and durability due to an increase in muscle mass, meaning they are nearly impossible to defeat through conventional means (Roronoa Zoro compared their endurance to that of Zombies, as they are able to immediately get up after being struck down). According to Tony Tony Chopper, the virus' symptoms cause too much strain on the victim's body, leading to their eventual death in around a hour at best, as confirmed by Queen.

This virus can quickly spread from person to person through physical contact, with one victim being shown biting an uninfected person to transmit it. Because of this, fighting back the infected requires one to use a weapon or another object to avoid physical exposure to the virus. The only way to cure Ice Oni is through an antibody created by the virus' developer himself, Queen, who happens to have the only known existing sample somewhere in his person.

Wano Country Arc
When war broke out at the Live Floor in Onigashima between the Ninja-Pirate-Mink-Samurai Alliance and the Beasts Pirates, Queen fired Excite Bullets from a gatling gun at the enemy samurai, intending on closing off the room and spreading the virus to everyone in it.

Trivia

 * This virus is named after the children's game "freeze tag", which is known in Japan as "Ice Oni" (こおり鬼).
 * The effects of Ice Oni resembles the traditional depictions of a zombie apocalypse in fictional media, which sometimes have highly infectious viruses act as the catalyst for it.

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