Tree Fever

Tree Fever was a lethal disease that affected some Grand Line islands 400 years ago.

Symptom and Cure
The only known symptom is the appearance of some dark spots (resembling green rash or moss in the anime) on the skin. It can be transmitted from animals to plants and vice versa.

The only known cure so far is Conine, a substance extracted from the Kona Tree.

History
Four hundred years ago, this disease affected Jaya and most of the Shandia, who believed it to be a curse of the gods. To stop it, the dying Pantri (priest), Chiya, ordered others to sacrifice Mousse to the snake god Kashigami.

As the sacrifice was about to happen, the botanist Mont Blanc Noland landed on the island and found an affected native, Seto, and cured him. Noland then went on to kill Kashigami to stop the sacrifice. After some initial misunderstandings, the botanist was able to use Conine to cure all of the tribe.

To stop the spread of the disease, Noland and his crew chopped down the infected forest, also known as the sacred forest of Shandia, which caused a misunderstanding between the Shandia and Noland's crew.

Trivia

 * The Tree Fever symptom resembles the effects of Daft Green's toxic spores. Both of them make green spots appear on the skin.
 * Yorki's lethal disease, its symptoms (dark blots on the skin) and the way he contracted it (in a jungle), greatly resemble the Tree Fever. However, no links between the two diseases are confirmed.

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