Lineage Factor

The Lineage Factor is the blueprint of life itself, present in all living organisms. It was discovered by a research team led by Dr. Vegapunk and Vinsmoke Judge.

Overview
All lifeforms have the Lineage Factor, and by manipulating it from a young age the growth of a lifeform can be changed.

SAD
By applying Lineage Factor, Caesar Clown was able to create SAD, a key ingredient used in the development of artificial Devil Fuits known as SMILES, as explained by Trafalgar Law.

Enhanced Humans
Using the Lineage Factor, and later gene manipulation, Vinsmoke Judge was also able to enhanced humans, specifically his children, and some soldiers from his army that he later cloned. However, Judge found out that the process can have its failure rates, as Sanji remained as a normal human despite modifications.

Cloning
Vinsmoke Judge conducted several researches and experiments with the Lineage Factor, becoming able to artificially manufacture human beings to fill the soldier ranks of Germa 66. Those soldiers are known as "Clone Pawns" and they are made without the knowledge of their origin.

Trivia

 * The Lineage Factor is a reference to DNA, the molecule that contains all the genetic information of the host organism.