I have read in the SBS in an old volume., I don't remember the volume actually but a question is been asked to oda about what is major death that may occur in one piece that may affect the story.
The answer was unclear but it seems that he was referring that their will be a horrible death in the end of one piece of course nothing will happens to luffy but I have a theorys say that the victim of this death will be
Shankes because not only he fulfilled his place in the story but he is also the only yonko that his path is clean other yonkos considered as antagonists so he may die because he cannot make alliance with anybody..luffy is busy marine is totally against the pirates and world government is watching and planning.. What I am trying to say that shankes will die a tragic death the same as white beard but worse.
And guys do you think buggy will fight with shankes
Back to back at some point in this story.