I mean it depends on what u mean. If they did that, I think Crocodile would still be the first guy who Luffy evidently defeats. The second one if it was Boa would be beneficial cuz if everything went the same way it did, then although the straw hats would prolly lose they would prolly learn haki earlier if Boa fell in love w him. After that I think that Moria would be easy. I don't think Mihawk would be a villain cuz if Baratie still happened then Mihawk would only be interested in Zoro and would not fight him before he thought he was ready so that could be a training arc where they fought against those apes for training but they would prolly die against Doffy. Idk how they'd handle Kuma. Actually if all of them are the antagonists of sagas then i see the straw hats winning aside from against Mihawk