Buggy was originally going to be called "Boogie". The creator of One Piece, Eiichiro Oda, saw a movie and saw that the name "Boogie" was taken. Oda quickly thought up the new name so he changed it to "Buggy".
"Boogie" was drawn in a harder, more realistic style, making him look more like a traditional 'scary horror clown' (somewhat akin to other clown-themed villains such as DC Comics' Joker). This is a contrast to Buggy's more rounded and cartoonish face in the final version. Buggy's red nose was also made bigger and more of an important feature on his face in comparison to Boogie, who had a normal-looking nose.
In the manga, Buggy is introduced accosting and executing a crewman - whom he'd mistakenly thought insulted his nose - with a special Buggy Ball. In the anime, Buggy shows mercy to this crewman and spares him.
In the manga before passing out, Mohji tries to say that Luffy is a rubber man but could not say the words completely, causing Buggy to get the wrong idea of what Luffy did to Mohji to win the fight. Buggy later throws Mohji for not properly informing him that Luffy had the power of a Devil Fruit. In the anime, Mohji tried to tell Buggy that Luffy had eaten the Gomu Gomu no Mi but could only say the word Gomu before passing out. Unlike the manga, Cabaji is the one that threw Mohji, after Mohji got angry at him for his treatment of Richie.
In the manga, the Buggy Pirates are not revealed to be in Loguetown until the moment they trap Luffy on Gold Roger's scaffold. The anime establishes their presence earlier, and adds several gags with Buggy encountering Luffy but (possibly due to his cloak blocking his peripheral vision) failing to realize it until Luffy has wandered off.
Impel Down Arc
Also in the anime, his screentime is greatly expanded during the Impel Down arc: his canon scenes from the manga are expanded greatly, and additional all-new scenes have been added as well.
During the Marineford arc his on screen time is extended as to include comic relief in an otherwise violent and dark arc, and for the most part filler. Buggy seems less eager to take Whitebeard's head than he does in the manga. A new scene was shown in which Buggy was watching Whitebeard fight Blackbeard, with Buggy coming up with excuses of why he could not attack Whitebeard.
Buggy and Alvida comment on Luffy's actions in anime, and Buggy imagines that Rayleigh could be Luffy's uncle because of his family's history. These comments were not present in the manga.
Wano Country Arc
During the the flashback of Oden and the Roger Pirates before the start of the Third Act, Buggy's outfit is changed, being like the clothes he wore during the three-day confrontation against the Whitebeard Pirates a year earlier, but with a purple sash around his waist.
Translation and Dub Issues
Under the 4Kids-dubbed anime, Buggy received typical content edits: his crew's alcohol was censored into "grapefruit punch", blood was erased from his successful knifings, and Luffy's kick to his groin was redrawn as a kick to his shin. A "reverb" effect was also used whenever he spoke in anger, implying that his powers could "split" even his voice. Finally, his "after the battle" mini-arc was cut from final production, leaving his return at "Roguetown" unexplained.
His habit of attaching "flashy" to random words was completely dropped by the 4Kids anime, and downplayed by the Viz manga (which often uses substitutes such as "gaudy, "magnificently", "gloriously", etc.). The Funimation-dubbed anime—which gives his overall voice an inflection similar to Mark Hamill's portrayal of the Joker—portrays the habit much more consistently.
Post-timeskip, his Senryō Dōke (千両道化,Senryō Dōke? lit. "thousand-ryō clown") epithet has also been subject to different translations, as it is meant to parody the Japanese phrase Senryō Yakusha (千両役者,Senryō Yakusha? lit. "thousand-ryō actor"), a term for extremely popular film stars and other entertainers. Both the Viz manga and the Funimation anime render this epithet as "Genius Jester", combining the general concept with an alliterative motif; in contrast, most fan translations use either "Star Clown" or the more literal "Thousand-Piece Clown".
Buggy appeared in Cross Epoch alongside the Straw Hats paired with Pilaf from Dragon Ball. Coincidentally, they are both voiced by Shigeru Chiba from their respective series.
In the six Japanese popularity polls about One Piece characters, Buggy is ranked, from the first to the sixth, in the 7th, 20th, 30th, 21th, 34th, and 35th place.
In an early interview for Shonen Jump, Oda once stated Buggy was his favorite villain; however, over time Oda has listed other villains as his favorite.
Buggy is the first villain to appear in the series who is a Devil Fruit user, and also the second character in the series to be one, after Luffy himself. He is the also first Devil Fruit user whom Luffy has fought.
He is seen amongst the audience of the theater in a trailer for Movie 6, even though he himself has no part in the story.
Like many other characters, Buggy has a distinct laugh, "Gyahahahahaha!"
During Oden's flashback Buggy is depicted with a more childish design and voice in spite tooking place some years after other flashbacks where Buggy is depicted with a more mature design and his adult voice.
In 2020, a gene in the fruit fly species Drosophila melanogaster was named Baramicin A, after Buggy. The gene produces a protein which is split into multiple parts, akin to Buggy's Devil Fruit power.
Buggy's birthday, August 8, comes from his Devil Fruit's name since 8-8 can be derived from ba-ra. He shares his birthday with Hatchan.
In the manga, Buggy is usually drawn with his mouth open, causing one fan to ask Oda to draw him with his mouth shut.
A fan asked Oda if Buggy's penis is also able to split and fly off. Oda replied "his penis can fly too" as every part of Buggy's body could fly off, except his feet.
A fan asked Oda if Buggy can bleed when using his Devil Fruit powers, only for Oda to reply that it would make him appear too scary.
In reference to Buggy and Shanks' "which is colder" argument, a fan asked Oda who got it right. Oda went on to explain that the Arctic was just a mass of ice and the Antarctic was a continent, which was made of land. Since land is colder than the sea (and the Arctic is frozen sea whereas the Antarctic is frozen land), Buggy was wrong.