Isa is a middle-aged woman with short, brown hair. She wears a long, tan dress with a brown vest and brown shoes. When she was younger, she wore a long brown dress with red dots. Like all Shandia, Isa has the short wings associated with their species.
Isa is Aisa's mother and she cares for her as such. Raki may also be her niece, since she calls Isa "aunt" (おばさん obasan?), although the terms is often used out of respect for elderly. Isa is also close enough to Raki that Raki confided to her about how she feared Wyper and his aggressive nature.
Years ago, Isa sat in her home with Aisa and Raki while Wyper and Gan Fall clashed outside. She commented to Raki on how her daughter always cried during tense times in the village, and Raki asked her about Wyper's aggressive behavior.
Sky Island Saga
When Enel was preparing to destroy Skypiea, the Shandia village tried to evacuate. Isa called out to the Shandia Chief about Aisa's absence, and he said he hoped that she was with one of the village's warriors.
- One Piece Manga and Anime — Vol. 28 Chapter 256 (p. 5-6) and Episode 168, Isa and Raki talk about Aisa and Wyper.
- One Piece Blue Deep: Characters World (p. 212), Her name is revealed.
- One Piece Manga and Anime — Vol. 30 Chapter 285 (p. 15) and Episode 186, Isa and the Shandia Chief evacuate from their village.
- One Piece Manga — Vol. 28 Chapter 256, Raki calls Aisa's mother "obasan".