One Piece Wiki

The Isshi-20 were the twenty most skilled doctors on Drum Island, whom Wapol took for himself in order to make his subjects dependent on him for their services.[1]

The Isshi-100 are the Isshi-20 renamed two years after their introduction, as they have recruited eighty additional doctors, becoming a group of one hundred doctors. They are now led by Kureha.[2]


The Isshi-100 are one hundred different doctors who dress in scrubs with sunglasses. They constantly have surgery mask and gloves on them. They are all of varying height with similar builds and most of the time stand as if prepared for surgery.[1] The Isshi-20 from two years ago wore pink scrubs, but the color of the scrubs the Isshi-100 are currently wearing remains unconfirmed.

Abilities and Powers

The Isshi-20 were the some of the most highly skilled doctors of Drum Island. Their external injuries unit was skilled enough to save Wapol's life even after he was decapitated; hilariously, he didn't even realized that fact until he was informed of it, for the surgeons have yet to complete the medical procedure. They use various techniques, such as cutting with a scalpel, stitching injuries, setting metal plates, and reinforcing them with a hammer.[1]

As the Isshi-100, their capabilities as doctors remain to be seen.



During King Wapol's Doctor Hunt, he ordered all doctors on Drum Island to live under his direct command, while eliminating those who did not comply either by banishment or killing. This was done to force the citizens to grovel to Wapol for medical help, so his tyrannical rule would be unopposed.[3]

The twenty doctors who complied became known as the Isshi-20 and were the only doctors on the island left aside from Kureha and Hiriluk.[3] While they remained under Wapol's control, they secretly despised him as the rest of the people did. However, they gave in to the king in order to remained safe.

One day, the Isshi-20 ordered members of the Wapol’s security force in Robelle to pick mushrooms, as they were researching their effectiveness against illnesses. This lapse in security allowed Hiriluk and Tony Tony Chopper to attempt to treat the town’s ill citizens, though they failed at it.[4]

Word got out that the Isshi-20 became ill, putting the country in crisis. Hiriluk decided to travel to the Drum Castle to save them. However, the Isshi-20 were not actually sick, and the rumor was created to lure Hiriluk and Kureha to Wapol, though only Hiriluk came.[5] When Hiriluk arrived at the castle, he saw the Isshi-20 in good health and realized that he had been tricked. Hiriluk fell to his knees, thankfully crying that the doctors were safe. Terminally ill and poisoned, he then decided to take his own life, speaking on his legacy before blowing himself up.[6]

Upon seeing the rogue doctor Dr. Hiriluk's noble sacrifice, the Isshi-20 became determined not to give up hope. To this end, they continued to refine their medical research and techniques under Wapol's tyrannical control in hopes of helping their compatriots someday.[7] When Wapol fled the kingdom due to a a fearsome enemy's attack, he took the Isshi-20 with him.[8]

Arabasta Saga

Drum Island Arc

After Wapol and his crew returned to Drum Island, Dalton struck Wapol down, slashing him across the chest. Kuromarimo ordered the external injuries squad to operate, and they used their medical skills to treat him. When Wapol sighed in relief that he was saved, the doctors panicked, as they had yet to reattach his head.[1] When an avalanche erupted, the Isshi-20 asked Wapol to let them ride Robson with him, but the king refused, leaving them behind to fend for themselves.[9]

Having survived the avalanche, the Isshi-20 mobilized to save Dalton, who had been gravely injured by Chess. The townspeople and Straw Hat Pirates were reluctant to trust them, but they revealed that they hated Wapol and were inspired by Hiriluk’s sacrifice to never give up hope. The doctors saved Dalton, but when he regained consciousness, he stormed out of where he was being treated and declared that he still had to stand up to Wapol. The doctors tried to dissuade him, but Dalton decided to go with the help of the Straw Hat Pirates.[7]

After Wapol was defeated, they were forgiven by the people of the island and rejoined them as citizens of the new Sakura Kingdom.

Fish-Man Island Saga

From the Decks of the World

Two years later, the Isshi-20 grew to become the Isshi-100, working under Kureha at Sakura Kingdom's medical center. They now have a new logo: a black flag combining the cross from Chopper's hat with a silhouette of what looks like Hiriluk's hat.[2]

Translation and Dub Issues

"Isshi" is derived from ishi (医師?), which means "doctor". In the English version, the Isshi-20 are accurately translated as "doctors" or "MDs", the last, meaning Doctor of Medicine (from the Latin Medicinae Doctor).


  1. 1.0 1.1 1.2 1.3 1.4 One Piece Manga and Anime — Vol. 15 Chapter 136 (p. 9-10) and Episode 82, The Isshi-20 treat Wapol after Dalton injures him.
  2. 2.0 2.1 2.2 2.3 One Piece Manga — Vol. 65 Chapter 637, cover story: From the Decks of the World Vol. 21, Kureha and the Isshi-100 are reintroduced.
  3. 3.0 3.1 One Piece Manga — Vol. 16 Chapter 141 (p. 11, 13), Hiriluk and Kureha discuss the Isshi-20.
  4. One Piece Manga — Vol. 16 Chapter 142 (p. 13), The Isshi-20 ask Robelle’s security force to pick mushrooms for their research.
  5. One Piece Manga — Vol. 16 Chapter 144 (p. 5, 8-9, 18-19), Wapol spreads a false rumor that the Isshi-20 are ill to lure our Hiriluk.
  6. One Piece Manga — Vol. 16 Chapter 145 (p. 2-5, 8), Hiriluk learns that the Isshi-20 are not sick and kills himself in front of them and Wapol.
  7. 7.0 7.1 One Piece Manga — Vol. 17 Chapter 147 (p. 3-4, 13), The Isshi-20 reveal the impression Hiriluk’s sacrifice left on them and save Dalton.
  8. One Piece Manga and Anime — Vol. 15 Chapters 133134 and Episode 80, Dalton explains how Wapol and his men abandoned Drum when the Blackbeard Pirates attacked.
  9. One Piece Manga — Vol. 16 Chapter 137 (p. 14), Wapol abandons the Isshi-20 in an avalanche.

Site Navigation