KYP is a gas that when inhaled impairs the victim as if they were drunk or otherwise intoxicated.
Because the effects of this gas simulate alcohol intoxication, targets with a high degree of alcohol tolerance (such as Zoro and Nami, whose body Sanji was inhabiting) are capable of resisting the inebriation enough to not be as immediately affected. 
- One Piece Manga and Anime — Vol. 68 Chapter 669 and Episode 595, The Yeti Cool Brothers used KYP against Zoro, Sanji and Brook.
- One Piece Manga and Anime — Vol. 67 Chapter 665 and Episode 591, The Yeti Cool Brothers used KYP to knock Zoro, Sanji, and Brook unconscious.
- One Piece Manga and Anime — Vol. 67 Chapter 667 and Episode 593, The Yeti Cool Brothers mention the usage of KYP.
- One Piece Manga — Vol. 68 Chapter 669 (p. 5-6), Zoro and Nami (Sanji) show greater resistance towards KYP.