It first appeared in Chapter 162 and Episode 98 when Luffy ate one instead of lizard meat, without thinking about it. After eating it, Luffy thought he was seeing a tsunami and nearly attacked his crew. Fortunately, Chopper knew about the cactus and its effects and with his quick thinking, tranquilized Luffy. The effect had worn off by the time Luffy woke up. This happened a second time when Luffy ate it, this time thinking he was fighting Crocodile.
- Some species of cactus have a psychoactive chemical held within called mescaline. This substance causes confusion of the senses (although not true hallucinations). This is most likely the origin of the Mescal cactus's name.