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Poison is a general term that refers to natural venom and chemical weapons that are harmful to organic lifeforms. Poison can come in different forms and phases, and it can have various effects on the victims, depending on its composition. This can range from paralysis to death. Poison can be either created by human chemistry, or secreted naturally from animals or plants as a defense mechanism.


Although poison can be harmful to the body, some of them have a counteracting agent, known as an antidote (解毒剤 gedokuzai?).[2] They can defuse the poison within the body, saving the victims from death or other harmful effects. However, some poisons may not have an antidote, or some antidotes may be difficult and time-consuming to create.[3]

Other Treatments

Outside of antidotes, there are other forms of treatment which can allow a person who has been poisoned to survive. However, these treatments are rare, being tied to unique abilities. They include Ivankov's Devil Fruit-based hormone treatments, and Vinsmoke Reiju's ability to absorb and suck out poisons. Through the use of her Shibo Shibo no Mi, Charlotte Smoothie can also wring liquids, including poisons, out of human bodies.

Poison in One Piece

In the series, there are several characters who use poison to fight. They gain a huge advantage in battle, as their opponents are weakened by the toxins and it is not difficult for one to be poisoned (as opposed to a swordsman who can block sword slashes, or someone like Monkey D. Luffy who takes little damage from blunt attacks like punches), which gives the users more opportunities to strike.[4][5]

Monkey D. Luffy has developed an extremely high resistance (if not quasi-immunity) to most poison. Primarily due to his near-death experience against Magellan's poisonous Devil Fruit, he started producing antitoxins (antibodies) to combat future poisons and foreign toxins without noticing.[6] Vinsmoke Reiju, whose epithet is "Poison Pink" (ポイズンピンク Poizun Pinku?), is immune to poison and can even consume it as a form of nourishment. She described the Armored Stonefish toxin as a delicacy, after absorbing a quantity of the poison sufficient to kill a giant.[7]

Certain Devil Fruit users gain immunities from poisons due their respective powers being affiliated with poison, such as Magellan[8] and Caesar Clown (Poisonous Gas).[9] In Magellan's case however, he is still affected by diarrhea after consuming too much poison.[8]

Poison-Weapon Users

  • Don Krieg uses the Deadly Poison Gas Bomb: MH5, which is a poison-gas grenade launcher that creates a large cloud poison, usually lethal to those who breathe it. Krieg claimed that the MH5 is strong enough to annihilate an entire village. Krieg and his men are given gas masks to protect themselves from it. The only known antidote is contained within the gas masks as stated by Zeff. He instead uses poisonous suction cups in the 4Kids Entertainment dub instead of spears.[1]
  • Nami, during her eight years of servitude under the Arlong Pirates, she tried many times to kill Arlong, which included attempting to poison him.[10]
  • Crocodile uses a golden-alloy hook with a hidden hook inside that contains scorpion venom. The poison appears to be acidic in large quantities and is concentrated enough to dissolve rocks. Upon being afflicted by the poison, the victim would be paralyzed and would eventually die from cardiac arrest.[4] Nico Robin was carrying a bottle of antidote for this poison.[2]
  • Wanze uses a giant knife covered in a one-hit sure kill deadly poison in his Ramen Kenpo's final technique: Noodle-Cutting Poisonous Kitchen-Knife.[11]
  • The unnamed pirate crew that massacred the Rumbar Pirates coated their weapons with poison to give themselves an edge in battle. As the Rumbar Pirates' doctor was killed in battle, the crew had no means of saving themselves from death.[12]
  • Duval uses a harpoon gun with the ammunition being coated with scorpion poison. The poison will kill the victim within three minutes.[13]
  • The New Fishman Pirates' Hyper Toxic Squadron used poison-based weapons. The poison contained in their weapons is very strong, as just one prick is enough to kill a person instantly.[14]
  • Hyouzou a blue-ringed octopus merman who can inject deadly venom into opponents and coat his swords with it.[6][15]
  • Yeti Cool Brothers uses bullets containing the sleeping gas KYP and other types of poison.[16]
  • Caesar Clown developed various poison gas weapons: a weapon of mass destruction out of H2S, and compressed it into a giant mass of slime, called Smiley,[17] and a weapon of mass destruction called Koro that will leave the poisoned victims a window of 48 hours before it becomes untreatable.[18]
  • Gladius uses poison on the tip of his hair, turning them into poisonous needles when used alongside his ability.[19]
  • Vinsmoke Reiju uses poison in combat, usually by secreting it and injecting it into opponents as she makes physical contact.[20]

Devil Fruit Based Poisons

There are certain Devil Fruit powers that can grant its eaters the ability to create poison.

  • Boa Marigold: eater of the Hebi Hebi no Mi, Model: King Cobra, which allows her to transform into a King Cobra, and allows her to spit venom at her opponents.[21]
  • Magellan: eater of the Doku Doku no Mi, this grants him the ability to create various types of poison, as well as makes him immune to all forms of poison.[8] Each of them have their various effects. Alone, these poisons seem to have an antidote all their own, but if accumulated, curing them could prove difficult, if not impossible.[3]
  • Hydra: a semi-corrosive liquid poison that causes lethal nerve paralysis until the victim dies after 24-hours of pain. The liquid can also be launched in bubbles known as "Poison Blowfish". Fire seems to somewhat neutralize it, while wax and stone are resistant to it.
  • Chloro Ball: a bubble that releases a tear gas poison and immobilizes the victims through severe sneezing. Guards of Impel Down wear gas masks to protect themselves from this.
  • Poison Cloud: a widespread poisonous cloud that slowly robs the victims of their vision, hearing, and strength. Guards of Impel Down wear gas masks to protect themselves from this.
  • Kinjite: Magellan's ultimate poison, it spreads like a disease upon contact with anything, even inorganic materials like wax and rocks. It causes the victims to die instantly once the poison spreads completely through the infected body. It is capable of destroying all of Impel Down.
  • Caesar Clown: user of the Gasu Gasu no Mi, which allows him to create, control, and transform into gas at will. His gas is shown to exhibit poisonous qualities.[9]

Anime Only


  • Amber Lead: a white-colored ore, native to Flevance, that leaves behind trace amounts of poison in individuals exposed to it, which will build up from extended exposure and be passed onto the next generation as birth defects, shortening lifespans of future generations until the bloodlines reach extinction at young age.[23]
  • Amiudake: a very poisonous mushroom that will kill anyone who eats it in one hour.[24]
  • Desert Strawberry: a poisonous spider that strongly resembles a strawberry, killing anyone who eats it after a few hours, and spreads its toxin after, poisoning anyone in the vicinity.[25]
  • Giant Python: a gigantic snake that releases very corrosive venom.[26]
  • Yuda: ferocious and poisonous sea serpents that even Sea Kings do not dare attack.[27]
  • Puzzle Scorpions: very poisonous scorpions that can combine into gigantic centipedes.[28]
  • A giant jellyfish in the underworld of the sea, which killed a giant fish that ate it.[29]
  • Armored Stonefish: a giant fish whose skin is extremely poisonous, enough to instantly kill those who consume them in normal circumstances, even a giant. Even Luffy's built up resistance could not stand up to the venom, only preventing him from dying immediately, and his condition worsened in a short time span, as none of the antidote aboard of his ship worked. Reiju, however, considered this toxin as a delicacy, and ate it without consequences.[30][7]


  • Agehaguera: a giant butterfly that releases toxic pollen when it flaps its wings.[31]
  • Daft Green: a species of tree that releases deadly spores.[31]


  1. 1.0 1.1 One Piece Manga and Anime — Vol. 7 Chapter 62 and Episode 27, Krieg uses the MH5 in an attempt to wipe out Baratie's chefs.
  2. 2.0 2.1 One Piece Manga and Anime — Vol. 24 Chapter 217 and Episode 130, Robin gives Cobra the antidote to Crocodile's hook to administrate on Luffy.
  3. 3.0 3.1 One Piece Manga and Anime — Vol. 55 Chapter 536 and Episode 437, Impel Down doctors claim it is impossible to cure a large accumulation of poison.
  4. 4.0 4.1 One Piece Manga and Anime — Vol. 22 Chapter 205 and Episode 104, The moment Crocodile's scorpion hook sliced into Luffy's skin, he started to waver.
  5. One Piece Manga and Anime — Vol. 55 Chapter 535 and Episode 436, Luffy could not attack Magellan without being poisoned, and once drenched with it, Luffy instantly lost.
  6. 6.0 6.1 One Piece Manga and Anime — Vol. 62 Chapter 610 and Episode 529, Luffy is revealed to be immune to Hyouzou's deadly venom.
  7. 7.0 7.1 One Piece Manga and Anime — Vol. 82 Chapter 826 (p. 10-12) and Episode 785, Reiju absorbing the Armored Stonefish toxin out of Luffy.
  8. 8.0 8.1 8.2 One Piece Manga and Anime — Vol. 54 Chapter 528 and Episode 425, Magellan is revealed to be the eater of the Doku Doku no Mi.
  9. 9.0 9.1 One Piece Manga and Anime — Vol. 69 Chapter 681 and Episode 607, Caesar Clown is revealed to be the eater of the Gasu Gasu no Mi.
  10. One Piece Manga and Anime — Vol. 10 Chapter 88 (p. 11) and Episode 41, Arlong recounts how many times Nami attempted to kill him.
  11. One Piece Manga and Anime — Vol. 39 Chapter 372 and Episode 260, Wanze pulls out his poison-coated butcher's knife.
  12. One Piece Manga and Anime — Vol. 50 Chapter 487 and Episode 380, The Rumbar Pirates lost all their lives to poisoned weapons.
  13. One Piece Manga and Anime — Vol. 51 Chapter 494 and Episode 388, Duval launching harpoons coated with scorpion venom at the Straw Hats.
  14. One Piece Manga and Anime — Vol. 64 Chapter 635 and Episode 556, The Deadly Poison Squad prepares to counter Robin's limbs.
  15. One Piece Manga and Anime — Vol. 65 Chapter 646 and Episode 556, Hyouzou coats eight sabers with his own venom against Zoro.
  16. One Piece Manga and Anime — Vol. 68 Chapter 669 and Episode 595, The Yeti Cool Brothers use a variety of chemicals against their targets.
  17. One Piece Manga and Anime — Vol. 68 Chapter 668 and Episode 594, Caesar explains how he compressed poison gases into Smiley.
  18. One Piece Manga and Anime — Vol. 81 Chapter 811 (p. 3-15) and Episode 761, Caesar explains his Koro gas weapon, and the Straw Hats counter it.
  19. One Piece Manga — Vol. 77 Chapter 773, Gladius launches his poison-coated hair.
  20. One Piece Manga — Vol. 86 Chapter 869, Reiju kicks Charlotte Smoothie's arm, simultaneously injecting it with poison.
  21. One Piece Manga and Anime — Vol. 53 Chapter 519 and Episode 413, Marigold spitting poison at Luffy.
  22. 22.0 22.1 One Piece Movie — Episode of Chopper Plus: Bloom in Winter, Miracle Sakura, Musshuru is revealed to have eaten the Noko Noko no Mi.
  23. One Piece Manga and Anime — Vol. 76 Chapter 762 (p. 4) and Episode 701, Doflamingo tells Jora that Amber Lead Syndrome is a type of poisoning, not contagious disease.
  24. One Piece Manga and Anime — Vol. 16 Chapter 143 and Episode 86, Kureha strikes Chopper for giving Hililuk a lethally poisonous mushroom.
  25. One Piece Manga and Anime — Vol. 18 Chapter 157 and Episode 94, People believed Ace ate a Desert Strawberry and died, when he was only asleep.
  26. One Piece Manga and Anime — Vol. 27 Chapter 255 and Episode 168, Nola spits highly corrosive venom.
  27. One Piece Manga and Anime — Vol. 53 Chapter 516 and Episode 409, Yuda are noted for their ferocity and poison.
  28. One Piece Manga and Anime — Vol. 54 Chapter 529 and Episode 430, Puzzle Scorpions are noted for their toxicity.
  29. One Piece Manga and Anime — Vol. 62 Chapter 606 and Episode 526, A giant fish died by eating a giant jellyfish.
  30. One Piece Manga and Anime — Vol. 82 Chapter 825 (p. 10-11) and Episode 784, Luffy poisoned from eating the skin of the Armored Stonefish.
  31. 31.0 31.1 One Piece Movie — One Piece Film: Strong World, Some of Indigo's modified plants and animals produce deadly poison.

External Links

  • Poison – Wikipedia article about poison.
  • Antidote – Wikipedia article about antidotes, the cure of poisons.
  • Mithridatism – Wikipedia article about the body developing immunity after surviving from poison.

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