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For the chapter of the same name, see Chapter 690.

SAD is a substance produced in a lab within Punk Hazard, the SAD Production Room, and kept within a huge metal vat.

It was first alluded to in a conversation by Vergo,[2] before being revealed to be Trafalgar Law's true objective on Punk Hazard.[3]


The full SAD mechanism in the manga.

When it was first seen, SAD was being kept in a large metallic vat hooked up to several tubes and a prominent nuclear symbol on it. After the vat holding the refined SAD was split open by Law, the substance is revealed to be somewhat of a foamy mixture similar to wax.[1]


SAD is a particularly unique substance and it is one of the few things needed to create SMILEs, which are artificial Zoan Devil Fruits.[4] Caesar Clown created it via the practical application of Vegapunk's[5] and Vinsmoke Judge's[6] discovery of the universal genetic blueprint: the Lineage Factor.[5] The substance itself is a mix of Lineage Factors from a wide variety of animals, and when the SAD is transmitted into fruits to create SMILEs, the Lineage Factor is intended to alter the user's body and give them the characteristics of a specific type of animal.[7]

According to Shinobu, the SAD formula is still incomplete. Thus, the SMILE fruits it produced have an extremely high risk factor; only a 10% chance of success in granting artificial Zoan-like enhancements to consumers, with a 90% majority not getting any powers and only suffering the side effects. While successful SMILE's mimic a real Devil Fruit's weakness of taking away the eater's ability to swim, the duds, in addition to taking away the eater's ability to swim, have an added side effect of taking away the eater's ability to express negative emotions, causing them to constantly smile and laugh, regardless of how they actually feel.[8]

Caesar is the only person in the world who knows how to manufacture SAD. As such, SAD is very valuable, so much so that Donquixote Doflamingo instantly figured out Law's intentions regarding the SAD storage room, being aware that its destruction would have been disastrous to his underworld empire.[9]

It has the potential to cause anarchy within the New World, depending on the one who wields it.[2] It also might have some radioactive properties, as the symbol for radioactive substances appeared on the tank Law was looking at; and Law himself noted that the laboratory will soon explode after the state he left the SAD production room in.[10][11]


Dressrosa Saga

Punk Hazard Arc

The SAD production room destroyed.

Vergo arrived on Punk Hazard shortly after catching a ride on a SAD tanker ship that was leaving from Dressrosa.[2]

Trafalgar Law apparently went through great lengths to gain access to the SAD production room on Punk Hazard, joining the Seven Warlords of the Sea and then forming an alliance with the Straw Hat Pirates.[3] He eventually succeeded amidst the chaos in the research facility, but Vergo contacted Doflamingo and reported it. Vergo was ordered to stop Law from taking the SAD and execute him for his betrayal,[9] which leads to the two of them battling in the production room.[12]

After Law and Smoker engaged and defeated Vergo, Law broke the production machines, crippling the production of SAD.[1] Due to this, afterwards the entire room exploded with Vergo inside of it.[11]

Dressrosa Arc

Despite the destruction of the production facility in Punk Hazard and Caesar's captivity, the Donquixote Pirates still possessed a decent quantity of SAD in their factory, as the dwarves continued their labor of cultivating SMILEs.[13] Ultimately, the remaining SAD supply, along with the SMILE Factory, were all destroyed when the dwarves rose up in revolt.[14]


  • SAD is similar to the Joker Venom from DC Comics, as both were created by someone with the moniker of "Joker" (Joker and Doflamingo) and cause a permanent grin with its victims.


  1. 1.0 1.1 1.2 One Piece Manga and Anime — Vol. 69 Chapter 690 (p. 17) and Episode 616, The physical form of SAD is seen when Law slices through the production room.
  2. 2.0 2.1 2.2 One Piece Manga and Anime — Vol. 68 Chapter 672 (p. 4) and Episode 598, Vergo says he came from Dressrosa on an SAD Tanker.
  3. 3.0 3.1 One Piece Manga and Anime — Vol. 69 Chapter 681 (p. 19) and Episode 607, Vergo realizes Law's objective to get to SAD.
  4. One Piece Manga and Anime — Vol. 69 Chapter 689 (p. 16) and Episode 615, Caesar Talks about his dealings.
  5. 5.0 5.1 One Piece Manga and Anime — Vol. 70 Chapter 698 (p. 16-17) and Episode 625, Law explains what he knows about SAD and SMILEs to the Straw Hats.
  6. One Piece Manga and Anime — Vol. 84 Chapter 840 (p. 3) and Episode 802, Yonji talks about Judge's past.
  7. SBS One Piece Manga — Vol. 99 (p. 134), The creation and composition of SAD is explained in further detail.
  8. One Piece Manga and Anime — Vol. 94 Chapter 943 (p. 10) and Episode 941, Shinobu Talks about SAD side effects.
  9. 9.0 9.1 One Piece Manga and Anime — Vol. 69 Chapter 682 (p. 7-9) and Episode 608, Doflamingo and Vergo talk about SAD.
  10. One Piece Manga and Anime — Vol. 70 Chapter 691 (p. 9) and Episode 617, Law leave the SAD lab.
  11. 11.0 11.1 One Piece Manga and Anime — Vol. 70 Chapter 694 (p. 8) and Episode 620, The SAD laboratory explodes.
  12. One Piece Manga and Anime — Vol. 69 Chapter 683 (p. 14-19) and Episode 609, Law and Vergo in the SAD laboratory.
  13. One Piece Manga and Anime — Vol. 74 Chapter 738 (p. 4-7) and Episode 671, Dwarves continued to produce SMILEs.
  14. One Piece Manga and Anime — Vol. 78 Chapter 779 (p. 5-6) and Episode 720, The Tontatta dwarves destroy the SMILE Factory.

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